On December 10, 1959, Severo Ochoa received the Nobel Prize in Physiology or Medicine, shared with his former student, Arthur Kornberg, ‘for his discoveries of the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid’. Sixty-five years after that event, this book wishes to pay tribute to a man who honored both universal science and the country in which he was born and educated, even if Spain’s unfortunate history led him to abandon his homeland. This book does not aim to recover, even in a moderately complete way, the complex and often itinerant life and work of Severo Ochoa. What we aim to offer is a kaleidoscopic view of a man who devoted his best energies to scientific research.